Uganda Launches Largest Malaria Vaccination Campaign to Protect Over 1.1 Million Children

The Ugandan Ministry of Health, in collaboration with international partners including Gavi, the Vaccine Alliance, the World Health Organization (WHO), UNICEF, PATH, and the Clinton Health Access Initiative (CHAI), has initiated a historic malaria vaccination campaign targeting over 1.1 million children under the age of two. This significant public health endeavor positions Uganda as the 19th African nation to incorporate the malaria vaccine into its routine immunization program, marking the most extensive rollout to date in terms of targeted districts and population. ​

Campaign Overview

The campaign was officially launched in Apac District, northern Uganda, a region identified for its high malaria transmission rates. The R21/Matrix-M malaria vaccine is being administered in a four-dose schedule at 6, 7, 8, and 18 months of age. The initial phase encompasses 105 districts with moderate to high malaria transmission, with plans to expand nationwide in subsequent phases. ​

Strategic Preparations and Partnerships

In preparation for this large-scale rollout, the Ministry of Health, supported by its partners, has distributed approximately 2.278 million doses of the malaria vaccine to the targeted districts. Comprehensive community mobilization and awareness campaigns have been conducted, engaging Members of Parliament, cultural and religious leaders, and implementing door-to-door outreach to ensure widespread community participation and acceptance. ​

Addressing Uganda’s Malaria Burden

Malaria remains a significant public health challenge in Uganda, contributing to approximately 4.8% of global malaria cases in 2023. The introduction of the malaria vaccine is a critical component of Uganda’s comprehensive malaria control strategy, aiming to reduce morbidity and mortality associated with the disease, particularly among young children who are most vulnerable. ​

Global Context and Future Directions

Uganda’s initiative aligns with broader continental efforts to combat malaria. As of December 2024, 17 African countries have incorporated malaria vaccines into their childhood immunization programs, reflecting a concerted effort to address the disease’s burden across the continent. The WHO’s Accelerating Malaria Vaccine Introduction and Rollout in Africa (AMVIRA) initiative continues to support member states in effectively implementing and scaling up malaria vaccination efforts. ​

Commitment to Child Health and Disease Prevention

The launch of this vaccination campaign underscores Uganda’s dedication to enhancing child health and preventing infectious diseases. By integrating the malaria vaccine into routine immunization schedules, the country aims to build on existing malaria control measures, including insecticide-treated mosquito nets and indoor residual spraying, to achieve a significant reduction in malaria cases and related deaths.